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Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus.
- Source :
-
Developmental & Comparative Immunology . Oct2014, Vol. 46 Issue 2, p413-422. 10p. - Publication Year :
- 2014
-
Abstract
- A ranavirus-induced thymus cDNA library was constructed from Chinese giant salamander, the largest extant amphibian species. Among the 137 putative immune-related genes derived from this library, these molecules received particular focus: immunoglobulin heavy chains (IgM, IgD, and IgY), IFN-inducible protein 6 (IFI6), and T cell receptor beta chain (TCRβ). Several unusual features were uncovered: IgD displays a structure pattern distinct from those described for other amphibians by having only four constant domains plus a hinge region. A unique IgY form (IgY(ΔFc)), previously undescribed in amphibians, is present in serum. Alternative splicing is observed to generate IgH diversification. IFI6 is newly-identified in amphibians, which occurs in two forms divergent in subcelluar distribution and antiviral activity. TCRβ immunoscope profile follows the typical vertebrate pattern, implying a polyclonal T cell repertoire. Collectively, the pioneering survey of ranavirus-induced thymus cDNA library from Chinese giant salamander reveals immune components and characteristics in this primitive amphibian. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTISENSE DNA
*IMMUNE response
*MOLECULES
*AMPHIBIANS
*T cells
Subjects
Details
- Language :
- English
- ISSN :
- 0145305X
- Volume :
- 46
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Developmental & Comparative Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 103726432
- Full Text :
- https://doi.org/10.1016/j.dci.2014.05.019