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Do Foxp3+ Regulatory T Cells (Treg Cells) Play a Role in the Immunopathogenesis of Primary/Idiopathic Minimal Change Disease?
- Source :
-
ISRN Pathology . 2014, p1-8. 8p. - Publication Year :
- 2014
-
Abstract
- Minimal change disease constitutes a major cause of nephrotic syndrome. It is regarded as a non-immune-complex mediated primary glomerulopathy and pathogenetically is characterised by podocyte injury and effacement of foot processes; therefore, it is also classified as a type of podocytopathy. T cell dysfunction with increased levels of a soluble glomerular permeability factor has been proposed to play a major role in the pathogenesis of minimal change disease. It has been therefore suggested that a dysfunction of regulatory T cells, the orchestrators of immune homeostasis, could be implicated in perpetuating T cell activation in this condition. However, the actual contribution of regulatory T cell dysfunction in the immunopathogenesis of primary minimal change disease is still largely unclear. We here propose a theoretical model based on the available evidence. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2090570X
- Database :
- Academic Search Index
- Journal :
- ISRN Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 103879998
- Full Text :
- https://doi.org/2014/640829