Single-stranded DNA Induces Ataxia Telangiectasia Mutant (ATM)/p53-dependent DNA Damage and Apoptotic Signals.

Authors :: Nur-E-Kamal, Alam
Tsai-Kun Li
Ailing Zhang
Haiyan Qi
Hars, Eszter S.
Liu, Leroy F.
Source :: Journal of Biological Chemistry. 4/4/2003, Vol. 278 Issue 14, p12475. 7p. 1 Black and White Photograph, 2 Diagrams, 16 Graphs.
Publication Year :: 2003
Abstract: Reports that the single-stranded DNA induces ataxia telangiextasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals. Single-stranded DNA's induced of apoptotic nuclease-mediated chromosomal DNA cleavage; Oligos induce up-regulation of p53 and activate ATM kinase; Preparation of cytoplasmic fraction; Measurement of reactive oxygen species production.

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