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Prognostic value of 18F-FDG PET/CT in patients with soft tissue sarcoma: comparisons between metabolic parameters.
- Source :
-
Skeletal Radiology . May2014, Vol. 43 Issue 5, p641-648. 8p. - Publication Year :
- 2014
-
Abstract
- <bold>Objectives: </bold>To investigate the relationship between volume-based PET parameters and prognosis in patients with soft tissue sarcoma (STS).<bold>Methods: </bold>We retrospectively reviewed 55 patients with pathologically proven STS who underwent pretreatment with (18) F-Fluorodeoxyglucose ((18)F-FDG) PET/CT. The maximum standardized uptake value (SUVmax), average SUV (SUVavg), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of primary tumors were measured using a threshold SUV as liver activity for determining the boundary of tumors. Univariate and multivariate survival analyses for overall survival were performed according to the metabolic parameters and other clinical variables.<bold>Results: </bold>Cancer-related death occurred in 19 of 55 patients (35 %) during the follow-up period (29 ± 23 months). On univariate analysis, AJCC stage (stage IV vs. I-III, hazard ratio (HR) = 2.837, p = 0.028), necrosis (G2 vs. G0-G1, HR = 3.890, p = 0.004), SUVmax (1 unit - increase, HR = 1.146, p = 0.008), SUVavg (1 unit - increase, HR = 1.469, p = 0.032) and treatment modality (non-surgical therapy vs. surgery, HR = 4.467, p = 0.002) were significant predictors for overall survival. On multivariate analyses, SUVmax (HR = 1.274, p = 0.015), treatment modality (HR = 3.353, p = 0.019) and necrosis (HR = 5.985, p = 0.006) were identified as significant independent prognostic factors associated with decreased overall survival.<bold>Conclusions: </bold>The SUVmax of the primary tumor is a significant independent metabolic prognostic factor for overall survival in patients with STS. Volume-based PET parameters may not add prognostic information outside of the SUVmax. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03642348
- Volume :
- 43
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Skeletal Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 104048531
- Full Text :
- https://doi.org/10.1007/s00256-014-1832-7