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Levels of interleukin-33 and interleukin-6 in patients with acute coronary syndrome or stable angina.
- Source :
-
Clinical & Investigative Medicine . Jul2013, Vol. 36 Issue 4, pE234-E234. 1p. - Publication Year :
- 2013
-
Abstract
- <bold>Purpose: </bold>The purpose of this study was to investigate the levels of interleukin-33 (IL-33) and interleukin-6 (IL-6) in patients with acute coronary syndrome or stable angina.<bold>Methods: </bold>Serum IL-33 and IL-6 were measured with Enzyme Linked Immuosorbent Assay (ELISA) in patients with acute coronary syndrome (ACS, n=40), and stable angina pectoris (SAP, n=43). IL-33 and IL-6 were also determined in 30 healthy subjects (control group).<bold>Results: </bold>The serum level of IL-33 in the ACS group (78.60±44.84 ng/L) was lower than in the SAP (102.58±37.21 ng/L, P<0.01) or control groups (130.24±10.17 ng/L, P<0.01). The serum level of IL-6 in the ACS group (39.90±12.64 ng/L) was higher than in the SAP (18.68±11.89 ng/L, P<0.05) or control groups (6.28±17.72 ng/L, P<0.05). There were no differences in serum levels of IL-33 and IL-6 among the single-, double- and triple-vessel lesion groups. IL-33 and IL-6 levels were negatively correlated with each other in the ACS (r=-0.871, P<0.01) and SAP groups (r=-0.788, P<0.01).<bold>Conclusion: </bold>The serum level of IL-33 was lower in patients with ACS or SAP and was negatively correlated with the serum level of IL-6. Thus, IL-33 and IL-6 may be used as biomarkers for evaluating inflammatory response and severity of coronary heart disease in patients with ACS or SAP. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0147958X
- Volume :
- 36
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Clinical & Investigative Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 104084862