Biochemical Analysis of the 20 S Proteasome of Trypanosoma brucei.

Authors :: Wang, Ching C.
Bozdech, Zbynek
Chao-lin Liu
Shipway, Aaron
Backes, Bradley J.
Harris, Jennifer L.
Bogyo, Matthew
Source :: Journal of Biological Chemistry. 5/2/2003, Vol. 278 Issue 18, p15800. 9p. 4 Diagrams, 3 Charts, 8 Graphs.
Publication Year :: 2003
Abstract: Describes the biochemical characterization of 20 S proteasome from the parasitic protozoan Trypanosoma brucei. Similarities and differences to the mammalian proteasome; Activity for cleavage after acidic amino acids in the 20 S proteasome complex; Importance of substrate sequence specificity of the T. brucei proteasome.