Transcription Factor Decoy Molecules Based on a Peptide Nucleic Acid (PNA)-DNA Chimera Mimicking Sp1 Binding Sites.

Determines whether double-stranded molecules based on peptide nucleic acids (PNA) and PNA-DNA-PNA chimeras could be capable of stable interactions with nuclear proteins belonging to the Sp1 transcription factor family. Ability to act as decoy reagents able to inhibit molecular interactions between Sp1 and DNA; Potential applications in gene therapy.