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Inhibition or Enhancement by 4 Pacific Island Food Plants Against Cancers Induced by 2 Amino–3-Methylimidazo[4,5-f]Quinoline in Male Fischer 344 Rats.
- Source :
-
Nutrition & Cancer . Feb2012, Vol. 64 Issue 2, p218-227. 10p. - Publication Year :
- 2012
-
Abstract
- A 1-yr carcinogenicity bioassay was conducted in rats fed 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), simultaneously with AIN-76/ high-fat (HF) diet alone, or with 10% starch replaced with kumara, pineapple, coconut, or taro, prepared as for a human diet. All of the non-IQ treated control, kumara, pineapple, or taro but not coconut-fed rats survived to 1 yr. None of the IQ-fed animals survived to 1 yr and although there were minor survival time differences among the groups, none was statistically significant. At sacrifice, IQ/HF controls had tumors in the skin, Zymbal's gland, ear canal, oral cavity, liver, and small intestine, totaling 32 among 20 animals. Kumara-fed rats had a similar tumor distribution but no tumors in the ear or oral cavity, and a total of 27 tumors among 20 animals, whereas pineapple-fed rats showed a somewhat lower tumor incidence (23/20 animals), including no small intestine lesions. Unexpectedly, a higher tumor incidence, especially of skin tumors, was seen in coconut and taro-fed animals (35/20 and 41/20 animals, respectively). In particular, the incidence of malignant liver tumors and gastrointestinal tumors were significantly increased in the taro-fed group in comparison with the kumara group. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01635581
- Volume :
- 64
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Nutrition & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 104516094
- Full Text :
- https://doi.org/10.1080/01635581.2012.638432