The effect of multidisciplinary lifestyle intervention on the pre- and postprandial plasma gut peptide concentrations in children with obesity.

Objective. This study aims to evaluate the effect of a multidisciplinary treatment of obesity on plasma concentrations of several gut hormones in fasting condition and in response to a mixed meal in children. Methods. Complete data were available from 36 obese children (age 13 3± 2.0 yr). At baseline and after the 3-month multidisciplinary treatment, fasting and postprandial blood samples. were taken for glucose, insulin, ghrelin, peptide YY (PYY), and glucagon-like peptide 1 (GLP-1). Results. BMI-SDS was significantly reduced by multidisciplinary treatment (from 4.2. ± 0.7 to 4 .0 ± 0.9, P <.01). The intervention significantly increased the area under the curve (AUC) of ghrelin (from 92.3 ± 18.3 to 9 7.9 ± 18.2p g / L, P <.01), but no significant changes were found for PYY . or GLP-1 concentrations (in fasting or postprandial condition). The insulin resistance index (HOMA-IR) remained unchanged as well. Conclusion. Intensive multidisciplinary treatment induced moderate weight loss and increased ghrelin secretion, but serum PYY and GLP-1 concentrations and insulin sensitivity remained unchanged. [ABSTRACT FROM AUTHOR]