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Enzyme potentiated desensitisation in treatment of seasonal allergic rhinitis: double blind randomised controlled study.
- Source :
-
BMJ: British Medical Journal (International Edition) . 8/2/2003, Vol. 327 Issue 7409, p251. 4p. 2 Charts, 1 Graph. - Publication Year :
- 2003
-
Abstract
- Abstract Objective: To assess the efficacy of enzyme potentiated desensitisation in the treatment of severe summer hay fever poorly controlled by pharmacotherapy. Design: Double blind randomised placebo controlled parallel group study. Setting: Hospital in Hampshire. Participants: 183 participants aged between 18 and 64 with a history of severe summer hay fever for at least two years; all were skin prick test positive to timothy grass pollen. 90 randomised to active treatment; 93 randomised to placebo. Interventions: Active treatment: two injections of enzyme potentiated desensitisation, given between eight and 11 weeks apart, each comprising 200 Fishman units of β glucuronidase, 50 pg 1, 3 cyclohexanediol, 50 ng protamine sulphate, and a mixed inhaled allergen extract (pollen mixes for trees, grasses, and weeds; allergenic fungal spores; cat and dog danders; dust and storage mites) in a total volume of 0.05 ml buffered saline. Placebo: two injections of 0.05 ml buffered saline solution. Main outcome measures: Proportion of problem-free days; global rhinoconjunctivitis quality of life scores assessed weekly during pollen season. Results: The active treatment group and the placebo group did not differ in the proportion of problem-free days, quality of life scores, symptom severity scores, change in quantitative skin prick provocation threshold, or change in conjunctival provocation threshold. No clinically significant adverse reactions occurred. Conclusions: Enzyme potentiated desensitisation showed no treatment effect in this study. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALLERGIC rhinitis
*RESPIRATORY allergy
*CLINICAL trials
*ENZYMES
Subjects
Details
- Language :
- English
- ISSN :
- 09598146
- Volume :
- 327
- Issue :
- 7409
- Database :
- Academic Search Index
- Journal :
- BMJ: British Medical Journal (International Edition)
- Publication Type :
- Academic Journal
- Accession number :
- 10464153
- Full Text :
- https://doi.org/10.1136/bmj.327.7409.251