Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stress-induced Activated Protein Kinase SAPK/JNK in Embryonic Stem Cells.

Authors :: Kishimoto, Hiroyuki
Nakagawa, Kentaro
Watanabe, Tomomi
Kitagawa, Daiju
Momose, Haruka
Jungwon Seo
Nishitai, Gen
Shimizu, Nao
Ohata, Shinya
Tanemura, Shuhei
Asaka, Satoshi
Goto, Takayuki
Fukush, Hiromichi
Yoshida, Hiroki
Suzuki, Akira
Sasaki, Takehiko
Wada, Teiji
Penninger, Josef M.
Nishina, Hiroshi
Source :: Journal of Biological Chemistry. 5/9/2003, Vol. 278 Issue 19, p16595. 7p. 2 Diagrams, 13 Graphs.
Publication Year :: 2003
Abstract: Examines the role of stress-activated protein kinase/c-Jun NH[sub 2]-terminal kinase (SAPK/JNK) in stress signaling. Generation of mkk7 mouse embryonic stem (ES) cells in addition to sek1 cells; Comparison of the two kinases in terms of the activation and phosphorylation of JNK; Generation of MKK7-deficient ES cells.

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