The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids.

Authors :: Brown, Andrew J.
Goldsworthy, Susan M.
Barnes, Ashley A.
Eilert, Michelle M.
Tcheang, Lili
Daniels, Dion
Muir, Alison I.
Wigglesworth, Mark J.
Kinghorn, Ian
Fraser, Neil J.
Pike, Nicholas B.
Strum, Jay C.
Steplewski, Klaudia M.
Murdock, Paul R.
Holder, Julie C.
Marshall, Fiona H.
Szekeres, Philip G.
Wilson, Shelagh
Ignar, Diane M.
Source :: Journal of Biological Chemistry. 3/28/2003, Vol. 278 Issue 13, p11312. 8p. 1 Color Photograph, 3 Charts, 6 Graphs.
Publication Year :: 2003
Abstract: Identifies the acetate anion as an agonist of human G protein-coupled receptor 43 (GPR43) during routine ligand bank screening in yeast. Functions of GPR41 and GPR43; Activation of the receptors by propionate and other short chain carboxylic acids; Expression of GPR41 primarily in adipose tissue; Localization of GPR43 in immune cells.

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