Anti-angiogenic Activity of the Recombinant Kringle Domain of Urokinase and Its Specific Entry into Endothelial Cells.

Authors :: Kwang Sei Kim
Yong-Kil Hong
Young Ae Joe
Yoon Lee
Joo-Young Shin
Hyo-Eun Park
Il-Ha Lee
Soo-Young Lee
Dong-Ku Kang
Soo-Ik Chang
Soo Il Chung
Source :: Journal of Biological Chemistry. 3/28/2003, Vol. 278 Issue 13, p11449. 8p. 1 Black and White Photograph, 2 Diagrams, 6 Graphs.
Publication Year :: 2003
Abstract: Investigates the kringle domain of urokinase plasminogen activator (uPA) for anti-angiogenic activity and a possible cellular mechanism of action. Important role played by uPA in inflammation, tissue remodeling, angiogenesis and tumor metastasis; Mechanism for the occurrence of the anti-angiogenic activity.

Subjects :: *PLASMINOGEN activators
*UROKINASE
*NEOVASCULARIZATION inhibitors
*ENDOTHELIUM

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