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AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase.
- Source :
-
Journal of Cell Science . 6/1/2003, Vol. 116 Issue 11, p2237. 10p. 8 Diagrams. - Publication Year :
- 2003
-
Abstract
- Examines the reassembly of the nuclear envelope (NE) at the end of mitosis requires targeting of the B-type lamin protein phosphatase, PP1, to the envelope by A-kinase anchoring protein AKAP149. Dissociation of PP1 from immunoprecipitated AKAP149; Transfection of AKAP149-derived RVXF peptides in G1 phase elicits lamin phosphorylation and disassembly; Regulation of the AKAP149-PP1 interaction at the NE.
- Subjects :
- *NUCLEAR membranes
*PHOSPHOPROTEIN phosphatases
*MITOSIS
*PROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 00219533
- Volume :
- 116
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Cell Science
- Publication Type :
- Academic Journal
- Accession number :
- 10474482
- Full Text :
- https://doi.org/10.1242/jcs.00432