Back to Search
Start Over
Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.
- Source :
-
Journal of the American Academy of Child & Adolescent Psychiatry . Sep2010, Vol. 49 Issue 9, p898-905.e3. 1p. - Publication Year :
- 2010
-
Abstract
- <bold>Objective: </bold>Genes likely play a substantial role in the etiology of attention-deficit/hyperactivity disorder (ADHD). However, the genetic architecture of the disorder is unknown, and prior genome-wide association studies (GWAS) have not identified a genome-wide significant association. We have conducted a third, independent, multisite GWAS of DSM-IV-TR ADHD.<bold>Method: </bold>Families were ascertained at Massachusetts General Hospital (MGH; N = 309 trios), Washington University at St. Louis (WASH-U; N = 272 trios), and University of California at Los Angeles (UCLA; N = 156 trios). Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. After applying quality control filters, association with ADHD was tested with 835,136 SNPs in 735 DSM-IV ADHD trios from 732 families.<bold>Results: </bold>Our smallest p value (6.7E-07) did not reach the threshold for genome-wide statistical significance (5.0E-08), but one of the 20 most significant associations was located in a candidate gene of interest for ADHD (SLC9A9, rs9810857, p = 6.4E-6). We also conducted gene-based tests of candidate genes identified in the literature and found additional evidence of association with SLC9A9.<bold>Conclusions: </bold>We and our colleagues in the Psychiatric GWAS Consortium are working to pool together GWAS samples to establish the large data sets needed to follow-up on these results and to identify genes for ADHD and other disorders. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08908567
- Volume :
- 49
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 104919391
- Full Text :
- https://doi.org/10.1016/j.jaac.2010.02.014