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Heat Shock Protein 70 Chaperone Overexpression Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model by Reducing Nuclear-Localized Mutant Androgen Receptor Protein.
- Source :
-
Journal of Neuroscience . 3/15/2003, Vol. 23 Issue 6, p2203. 9p. 4 Black and White Photographs, 3 Charts, 4 Graphs. - Publication Year :
- 2003
-
Abstract
- Presents a study which reported that overexpression of the inducible form of human HSP70 markedly ameliorated clinical and pathological phenotypes, and that this amelioration was correlated with the reduction of nuclear-localized mutant androgen receptor (AR) protein complexes in the mouse model of spinal and bulbar muscular atrophy. Materials and methods; Nondeleterious effects of HSP70 overexpression and generation of double-transgenic mice; Colocalization of HSP70 with mutant AR in the nuclei.
Details
- Language :
- English
- ISSN :
- 02706474
- Volume :
- 23
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 10493380
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.23-06-02203.2003