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Association between the DRB1*08032 histocompatibility antigen and methimazole-induced agranulocytosis in Japanese patients with Graves disease.
- Source :
-
Annals of Internal Medicine . 3/1/96, Vol. 124 Issue 5, p490-494. 5p. - Publication Year :
- 1996
-
Abstract
- <bold>Objective: </bold>To determine the association between HLA class II genes and methimazole-induced agranulocytosis in patients with Graves disease.<bold>Design: </bold>Case-control study.<bold>Setting: </bold>Kuma Hospital, which specializes in thyroid diseases, in Kobe, Japan.<bold>Subjects: </bold>24 patients with Graves disease who had methimazole-induced agranulocytosis diagnosed by peripheral granulocyte counts of less than 0.5 x 10(9)/L, and 68 patients with Graves disease treated with methimazole, who were free from agranulocytosis. Controls were 525 healthy, unrelated Japanese student volunteers at Kyushu University in Japan.<bold>Measurements: </bold>All HLA class II genes were analyzed for polymorphisms at the DNA level by using the polymerase chain reaction sequence-specific oligonucleotide probes method. The allele frequencies in the agranulocytotic Graves disease group were compared with those in the nonagranulocytotic Graves disease and control groups.<bold>Results: </bold>A strong positive association was seen in DRB1*08032 between the agranulocytotic group and both the control and nonagranulocytotic Graves disease groups.<bold>Conclusion: </bold>The HLA DRB1*08032 allele was strongly associated with susceptibility to methimazole-induced agranulocytosis, suggesting that cellular autoimmunity may be involved in its development. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00034819
- Volume :
- 124
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Annals of Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 105649824
- Full Text :
- https://doi.org/10.7326/0003-4819-124-5-199603010-00005