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Long-term statin use and psychological well-being
- Source :
-
Journal of the American College of Cardiology (JACC) . Aug2003, Vol. 42 Issue 4, p690-697. 8p. - Publication Year :
- 2003
-
Abstract
- : ObjectivesWe sought to study the effect of long-term statin use on psychometric measures in an adult population with underlying coronary artery disease (CAD).: BackgroundPrevious studies have suggested associations between cholesterol lowering and psychological well-being.: MethodsStudy subjects were recruited from an outpatient cardiology clinic. Psychological well-being was assessed at baseline and annually during follow-up. The exposure of interest was long-term statin use and the outcomes of interest were depression, anxiety, and hostility. We estimated the odds ratios (ORs) and 95% confidence intervals (CI) that represented the strength of association between statin use (vs. no use of any cholesterol-lowering drug) and the risk of having abnormal depression, anxiety, and hostility scores.: ResultsStudy subjects had an average follow-up of four years and maximum of seven years. Comparing the 140 patients who had continuous use of statins with the 231 patients who did not use any cholesterol-lowering drugs, statin use was associated with lower risk of abnormal depression scores (OR 0.63, 95% CI 0.43 to 0.93), anxiety (OR 0.69, 95% CI 0.47 to 0.99), and hostility (OR 0.77, 95% CI 0.58 to 0.93) after adjustment for the propensity for statin use and potential confounders. The beneficial psychological effects of the statins appeared to be independent of the drugs'' cholesterol-lowering effects.: ConclusionsLong-term use of statins among patients with CAD appeared to be associated with reduced risk of anxiety, depression, and hostility. [Copyright &y& Elsevier]
- Subjects :
- *STATINS (Cardiovascular agents)
*PSYCHOMETRICS
*CORONARY disease
*PREVENTION of mental depression
*ANTILIPEMIC agents
*PHYSIOLOGICAL adaptation
*COMPARATIVE studies
*EMOTIONS
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*MENTAL health
*RESEARCH
*EVALUATION research
*RETROSPECTIVE studies
*PSYCHOLOGY
ANXIETY prevention
Subjects
Details
- Language :
- English
- ISSN :
- 07351097
- Volume :
- 42
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of the American College of Cardiology (JACC)
- Publication Type :
- Academic Journal
- Accession number :
- 10570568
- Full Text :
- https://doi.org/10.1016/S0735-1097(03)00785-X