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The biology of IL-12: coordinating innate and adaptive immune responses
- Source :
-
Cytokine & Growth Factor Reviews . Oct2003, Vol. 14 Issue 5, p361. 8p. - Publication Year :
- 2003
-
Abstract
- Cytokines play critical roles in regulating all aspects of immune responses, including lymphoid development, homeostasis, differentiation, tolerance and memory. Interleukin (IL)-12 is especially important because its expression during infection regulates innate responses and determines the type and duration of adaptive immune response. IL-12 induces interferon-γ (IFN-γ) production by NK, T cells, dendritic cells (DC), and macrophages. IL-12 also promotes the differentiation of naı¨ve CD4+ T cells into T helper 1 (Th1) cells that produce IFN-γ and aid in cell-mediated immunity. As IL-12 is induced by microbial products and regulates the development of adaptive immune cells, IL-12 plays a central role in coordinating innate and adaptive immunity. IL-12 and the recently identified cytokines, IL-23 and IL-27, define a family of related cytokines that induce IFN-γ production and promote T cell expansion and proliferation. [Copyright &y& Elsevier]
- Subjects :
- *CYTOKINES
*IMMUNE response
*HOMEOSTASIS
*INTERLEUKIN-12
*DENDRITIC cells
*T cells
Subjects
Details
- Language :
- English
- ISSN :
- 13596101
- Volume :
- 14
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Cytokine & Growth Factor Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 10634059
- Full Text :
- https://doi.org/10.1016/S1359-6101(03)00043-1