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Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese
- Source :
-
Neuroscience Letters . Oct2003, Vol. 349 Issue 3, p209. 3p. - Publication Year :
- 2003
-
Abstract
- To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer''s disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 normal elderly controls in the Chinese population. Our data showed that the TF C1 homozygosity carriers had an increased risk of AD in subjects ≥75 years of age, showing that homozygosity for the TF C1 allele was associated with an approximately three-fold increased risk (<f>OR=3.57</f>, 95% CI, 1.24–10.27, <f>P=0.014</f>). No synergic effects were found between the APOE &epsiv;4 allele and TF gene polymorphisms. [Copyright &y& Elsevier]
- Subjects :
- *TRANSFERRIN
*APOLIPOPROTEIN E
*ALZHEIMER'S disease
*GENETIC polymorphisms
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 349
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 10695980
- Full Text :
- https://doi.org/10.1016/S0304-3940(03)00837-1