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Multivariate least squares regression applied to the spectrophotometric analysis of manidipine and its main photoproduct
- Source :
-
Il Farmaco . Sep2003, Vol. 58 Issue 9, p909. 7p. - Publication Year :
- 2003
-
Abstract
- The simultaneous quantitative assay of 1,4-dihydropyridine calcium antagonist manidipine and its main photodegradation by-product has been defined by using a multivariate calibration on UV spectra based on a classical least squares regression. Optimization of the procedure was achieved by means of a calibration model using suitable wavelength ranges singled out from a fractionation scheme thereat defined. Recovery values of 99 and 96% for the drug and the by-product, respectively, were found either in appropriately prepared mixtures and commercial formulations. Quantification limit for the photoproduct concentration was estimated as 1.0% for the reference samples. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0014827X
- Volume :
- 58
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Il Farmaco
- Publication Type :
- Academic Journal
- Accession number :
- 10809039
- Full Text :
- https://doi.org/10.1016/S0014-827X(03)00149-6