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α-Hydroxyphosphonate Oligonucleotides: A Promising DNA Type?
- Source :
-
Nucleosides, Nucleotides & Nucleic Acids . May2003, Vol. 22 Issue 5-8, p1061-1064. 4p. - Publication Year :
- 2003
-
Abstract
- The synthesis of monomers (S)-1, (R)-1 and 2 derived from (5′S)-, (5′R)-2′-deoxythymidine-5′-C-phosphonic acids and 2′,5′-dideoxythymidine-5′-C-phosphonic acids was elaborated. The protection of the 5′-hydroxyl by the methoxycarbonyl group was a key step of the synthesis. Prepared monomers were used for the solid-phase assembly of several types oligothymidylate 15-mers (S)-3, (S)-4, (S)-5, (R)-4 and (R)-5 containing the chiral 3′-O-P-CH(OH)-5″ internucleotide linkage. Their hybridization properties with dA15 and rA15 were studied as well as their resistance against nuclease cleavage. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MONOMERS
*PHOSPHONATES
*OLIGONUCLEOTIDES
*NUCLEOSIDES
*NUCLEIC acid hybridization
Subjects
Details
- Language :
- English
- ISSN :
- 15257770
- Volume :
- 22
- Issue :
- 5-8
- Database :
- Academic Search Index
- Journal :
- Nucleosides, Nucleotides & Nucleic Acids
- Publication Type :
- Academic Journal
- Accession number :
- 10833774
- Full Text :
- https://doi.org/10.1081/NCN-120022736