Back to Search
Start Over
Single-molecule insights into mRNA dynamics in neurons.
- Source :
-
Trends in Cell Biology . Aug2015, Vol. 25 Issue 8, p468-475. 8p. - Publication Year :
- 2015
-
Abstract
- Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular signaling, development, and synaptic plasticity. Single-molecule imaging of mRNAs in neurons and brain tissue has led to enhanced understanding of mRNA dynamics. Here we discuss aspects of mRNA regulation as revealed by single-molecule detection, which has led to quantitative analyses of mRNA diversity, localization, transport, and translation. These exciting new discoveries propel our understanding of the life of an mRNA in a neuron and how its activity is regulated at the single-molecule level. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09628924
- Volume :
- 25
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Trends in Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 108342893
- Full Text :
- https://doi.org/10.1016/j.tcb.2015.05.005