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Meningitis and a safe dexamethasone-eluting intracochlear electrode array.
- Source :
-
Cochlear Implants International: An Interdisciplinary Journal . Jul2015, Vol. 16 Issue 4, p201-207. 7p. - Publication Year :
- 2015
-
Abstract
- Objectives To evaluate the potential risk of pneumococcal meningitis associated with the use of a dexamethasone-eluting intracochlear electrode array as compared with a control array. Methods In two phases, adult Hooded–Wistar rats were implanted via the middle ear with an intracochlear array and were inoculated with Streptococcus pneumoniae 5 days post-surgery. Phase I created a dosing curve by implanting five groups (n = 6) with a control array, then inoculating 5 days later with different numbers of S. pneumoniae: 0 CFU, 103 CFU, 104 CFU, 104 CFU repeated, or 105 CFU (colony forming units). A target infection rate of 20% was aimed for and 104 CFU was the closest to this target with 33% infection rate. In phase II, we implanted two groups (n = 10), one with a dexamethasone-eluting array, the other a control array, and both groups were inoculated with 104 CFU of S. pneumoniae 5 days post-surgery. Results The dexamethasone-eluting array group had a 40% infection rate; the control array group had a 60% infection rate. This difference was not statistically significant with a P value of ≥0.5. Conclusion The use of a dexamethasone-eluting intracochlear electrode array did not increase the risk of meningitis in rats when inoculated with S. pneumoniae via the middle ear 5 days following implantation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14670100
- Volume :
- 16
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Cochlear Implants International: An Interdisciplinary Journal
- Publication Type :
- Academic Journal
- Accession number :
- 108376481
- Full Text :
- https://doi.org/10.1179/1754762814Y.0000000099