A Novel Variant Translocation t(8;16;21) (q22;q24;q22) in Acute Myeloid Leukemia Expressing both Myeloid and Lymphoid Markers.

We present a novel, rare but recurrent, variant three-way translocation of t(8;21), t(8;16;21)(q22;q24;q22), resulting in RUNX1-RUNX1T1 fusion gene in a patient with acute myeloid leukemia expressing both myeloid and lymphoid markers. Our patient was considered as a high risk patient based on his single blast population with immunophenotypic evidence of simultaneous myeloid and B-lymphoid differentiation, the unknown implications of t(8;16;21) and the presence of minimal residual disease shortly after the last chemotherapy cycle. However, he had an excellent outcome after allogeneic stem cell transplantation and he is well and fully functional 4 years post diagnosis. This case could be advisable for prognostic and therapeutic purposes. [ABSTRACT FROM AUTHOR]