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Asymmetric Conjugate Addition of Alkylzirconocenes to Cyclopent-4-ene-1,3-dione Monoacetals.
- Source :
-
Synthesis . 2015, Vol. 47 Issue 15, p2217-2222. 6p. - Publication Year :
- 2015
-
Abstract
- Copper-catalyzed asymmetric conjugate additions are powerful reactions that allow the formation of single-enantiomer building blocks in a few steps. However, highly enantioselective conjugate addition to five-membered-ring substrates is more challenging and is often neglected. Here, we report catalytic asymmetric 1,4-addition of alkylzirconocenes, formed in situ from readily available alkenes, to cyclopent- 4-ene-1,3-dione monoacetals. Good to high enantioselectivities are observed and the procedure tolerates various functional groups. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 47
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 108512568
- Full Text :
- https://doi.org/10.1055/s-0034-1379928