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Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?
- Source :
-
Lancet Neurology . Oct2003, Vol. 2 Issue 10, p595-604. 10p. - Publication Year :
- 2003
-
Abstract
- Dopamine replacement therapy (DRT) is the most effective treatment for Parkinson''s disease (PD); it provides substantial benefit for most patients, extends independence, and increases survival. A few patients with PD, however, take increasing quantities of medication far beyond those required to treat their motor disabilities. These patients demand rapid drug escalation and continue to request more DRT despite the emergence of increasingly severe drug-induced motor complications and harmful behavioural consequences. In this article we detail the features of compulsive DRT-seeking and intake in PD, in relation to theories of compulsive drug use. [Copyright &y& Elsevier]
- Subjects :
- *DOPAMINE
*NEUROTRANSMITTERS
*PARKINSON'S disease
*EXTRAPYRAMIDAL disorders
*BRAIN diseases
*MOVEMENT disorder treatments
*PARKINSON'S disease treatment
*BIOLOGICAL models
*COMPARATIVE studies
*RESEARCH methodology
*MEDICAL cooperation
*MOVEMENT disorders
*RESEARCH
*REWARD (Psychology)
*SUBSTANCE abuse
*DISEASE management
*EVALUATION research
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 14744422
- Volume :
- 2
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Lancet Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 10862259
- Full Text :
- https://doi.org/10.1016/S1474-4422(03)00529-5