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Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?

Authors :
Lawrence, Andrew D
Evans, Andrew H
Lees, Andrew J
Source :
Lancet Neurology. Oct2003, Vol. 2 Issue 10, p595-604. 10p.
Publication Year :
2003

Abstract

Dopamine replacement therapy (DRT) is the most effective treatment for Parkinson''s disease (PD); it provides substantial benefit for most patients, extends independence, and increases survival. A few patients with PD, however, take increasing quantities of medication far beyond those required to treat their motor disabilities. These patients demand rapid drug escalation and continue to request more DRT despite the emergence of increasingly severe drug-induced motor complications and harmful behavioural consequences. In this article we detail the features of compulsive DRT-seeking and intake in PD, in relation to theories of compulsive drug use. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
14744422
Volume :
2
Issue :
10
Database :
Academic Search Index
Journal :
Lancet Neurology
Publication Type :
Academic Journal
Accession number :
10862259
Full Text :
https://doi.org/10.1016/S1474-4422(03)00529-5