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Focal impairment in myocardial fatty acid imaging in the left anterior descending artery area, a strong predictor for cardiac death in hemodialysis patients without obstructive coronary artery disease.
- Source :
-
European Journal of Nuclear Medicine & Molecular Imaging . Sep2015, Vol. 42 Issue 10, p1612-1621. 10p. 1 Black and White Photograph, 1 Diagram, 4 Charts, 3 Graphs. - Publication Year :
- 2015
-
Abstract
- Purpose: We investigated whether impaired patterns of myocardial fatty acid imaging were associated with cardiac death in dialysis patients without coronary lesions. Methods: We prospectively enrolled 155 hemodialysis patients without obstructive coronary artery disease, who had been examined by single-photon emission computed tomography (SPECT) using the iodinated fatty acid analogue BMIPP. Uptake of BMIPP on SPECT was graded in 17 segments on a five-point scale (0, normal; 4, absent) and assessed as BMIPP summed scores. Of the enrolled 155 participants, we analyzed 95 who had BMIPP summed scores ≥ 6 (52 men and 43 women, 65 ± 11 years). BMIPP scores ≥ 2 in ≥ 2 consecutive segments in SPECT were defined as focal, and the others as non-focal pattern. Results: Of 95 participants analyzed, 42 (44.2 %) showed focal and 53 (55.8 %) non-focal type. During follow-up for 5.1 ± 2.0 years, 42 died of cardiac events. The occurrence of cardiac death was higher in the focal than in the non-focal group (30/42 [71.4 %] versus 12/53 [22.6 %], p = 0.001). In stepwise Cox hazard analysis, focal pattern was associated with cardiac death (hazard ratio 2.266), independent of impairment of BMIPP SPECT (BMIPP summed scores ≥ 12). The predictive potential of BMIPP SPECT for cardiac death was higher ( p < 0.001) in the left anterior descending artery area compared with other coronary territories. Conclusions: Focal impairment in myocardial fatty acid imaging in the left anterior descending area may strongly predict cardiac death in this population. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FATTY acids
*CARDIAC arrest
*HEART failure
*SUDDEN death
*HEMODIALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 16197070
- Volume :
- 42
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- European Journal of Nuclear Medicine & Molecular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 108632862
- Full Text :
- https://doi.org/10.1007/s00259-015-3120-8