P55: Intraocular non-hodgkin lymphoma: A case report.

Introduction: Intraocular non-Hodgkin lymphoma (IONHL) runs a uniformly fatal course. Once the central nervous system is involved, survival without treatment is very limited. Although treatment does not substantially improve the long term survival, it provides short term improvement in these patients. Observation: We report a case of an intraocular non-Hodgkin lymphoma in a patient treated at the Oncology Center Ibn Rochd of Casablanca. It was about a patient of 31 years with no specific pathological history, who presented in April 2013 with clinical symptoms of redness in the right eye and decreased visual acuity. Ophthalmological tests showed a right blindness and ocular ultrasound an incomplete posterior detachment of the retina with a cataract. This assessment concludes to an anterior right sclero-uveitis. The patient received systemic corticosteroids. Given the persistence of symptoms and the appearance of sclerotic nodules, an etiologic looking for a systemic disease was found normal. Cranio-orbital scanner objectified diffuse infiltration of the intraocular soft tissues and biopsy of nodules confirmed the diagnosis of peripheric TNHL. The complementary staging found submandibular and jugular-carotid lymph nodes with laryngeal thickening. Before the diagnosis of IONHL, the patient received chemotherapy (2 cures of DHAP) and local radiotherapy (45 Gy) followed by enucleation of the right eye. The evolution was marked by the death of the patient due to brain metastases with a term of 15 months. Conclusion: IONHL presents as the form of several clinical features. Treatment was initially based on radiotherapy. Recently, combination with chemotherapy has improved survival and tolerance, especially after the introduction of intra-vitreal chemotherapy. [ABSTRACT FROM AUTHOR]