Relevant Research Progress of Platelet Micropaticles.

Platelet microparticles (PMP) are the most abundant microparticles in the bloodstream which constituting microparticles come from a variety of cells. PMP are a heterogeneous population of vesicles. They are not only different from the exosomes which generated from the intracellular multivesicular bodies, but also different from the microparticles derived from megakaryocytes. PMP have intact membrane glycoprotein and lipid composition that is same with platelet. The diversity of PMP which induced by different activators play an important role in physiological function. PMP can work in coordination with platelet. Furthermore, it is now accepted that PMP mediate intercellular transfer of bioactive molecules for a better promotion of cell-cell communication, for instance, delivering membrane receptors, cytoplasmic proteins and even RNA to recipient cells. Recent researches have shown that the unusual level of PMP had found in patients with certain diseases, such as immune thrombocytopenic purpura, prostate cancer, rheumatoid arthritis, etc. This article reviewed the formation and diversity, generation, biological function of PMP and its related clinical diseases so as to promulgate the properties of PMP and multiple pathology progresses and relevant molecular mechanisms more inclusively and more correctly, to better guide the further clinical research, providing theoretical basis for new treatment methods. [ABSTRACT FROM AUTHOR]