Effect of drugs, iodine 131, and surgery on bone mineral density and bone turnover markers in hyperthyroid patients.

Objective To evaluate the impact of drug therapy, radioiodine therapy, and surgical therapy in bone mineral density and biochemical bone turnover markers in patients with hyperthyroidism. Methods A total of 186 female patients with hyperthyroidism were enrolled in the study. They received drug therapy, radioiodine therapy, or surgical therapy according to the disease course and their own wish. Bone mineral density and biochemical bone turnover markers were compared at the time of enrollment and after 2-year treatment. Results Bone mineral density increased and biochemical bone turnover markers decreased significantly in all patients in 3 groups. No difference between bone mineral density and bone turnover markers were found among the 3 groups. Conclusion Drug therapy, radioiodine therapy, and surgical therapy improve bone mineral density and decrease biochemical markers of bone turnover in hyperthyroid patients. [ABSTRACT FROM AUTHOR]