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Resequencing of early growth response 2 (EGR2) gene revealed a recurrent patient-specific mutation in schizophrenia.
- Source :
-
Psychiatry Research . Aug2015, Vol. 228 Issue 3, p958-960. 3p. - Publication Year :
- 2015
-
Abstract
- Abnormal myelination is considered as part of the pathophysiology of schizophrenia. We resequenced the genomic DNA of the EGR2 , which has a specific function in the myelination of peripheral nervous system, in 543 schizophrenic patients and 554 non-psychotic controls. We identified six known SNPs, which were not associated with schizophrenia. Nevertheless, we discovered 24 rare mutations, some of them were patient-specific, including a recurrent mutation (p.P173_Y174insP), which might be associated with the pathogenesis of schizophrenia. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01651781
- Volume :
- 228
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Psychiatry Research
- Publication Type :
- Academic Journal
- Accession number :
- 108786096
- Full Text :
- https://doi.org/10.1016/j.psychres.2015.05.035