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Transcription factor Nrf1 is negatively regulated by its O-GlcNAcylation status.
- Source :
-
FEBS Letters . Aug2015, Vol. 589 Issue 18, p2347-2358. 12p. - Publication Year :
- 2015
-
Abstract
- O -Linked N -acetylglucosamine transferase (OGT) was identified as an Nrf1-interacting protein. Herein, we show that Nrf1 enables interaction with OGT and their co-immunoprecipitates are O -GlcNAcylated by the enzyme. The putative O -GlcNAcylation negatively regulates Nrf1/TCF11 to reduce both its protein stability and transactivation activity of target gene expression. The turnover of Nrf1 is enhanced upon overexpression of OGT, which promotes ubiquitination of the CNC-bZIP protein. Furthermore, the serine/theorine-rich sequence of PEST2 degron within Nrf1 is identified to be involved in the protein O -GlcNAcylation by OGT. Overall, Nrf1 is negatively regulated by its O -GlcNAcylation status that depends on the glucose concentrations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 589
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 108808406
- Full Text :
- https://doi.org/10.1016/j.febslet.2015.07.030