CORRELATION BETWEEN HEART TYPE FATTY ACID BINDING PROTEIN SERUM LEVEL AND SOLUBLE ST2 IN ACUTE CORONARY SYNDROME PATIENTS.

Heart-type fatty acid-binding protein (H-FABP) is an early marker of myocardial ischemia even in the absence of frank necrosis. HFABP and N-terminal pro-B-type natriuretic peptide had independent prognostic value in addition to troponin and showed good correlation with infarct size. Soluble ST2 is released as a respond of mechanical stress under condition of acute myocardial infarction and heart failure. ST2 level showed weak correlation with neither NTproBNP. Elevated ST2 concentrations at admission in the setting of ACS are associated with higher creatine kinase concentrations, large infarct size, lower pre-discharge LVEF and predicts 30-days occurrence of heart failure or death after myocardial infarction. To analyze correlation between serum level of Heart Type Fatty Acid Binding Protein(HFABP) and Soluble ST2 on Acute Coronary Syndrome patient. This was a cross-sectional study in ICCU dr Soetomo Hospital. RELIA TM Immunoassay Diagnostic Instrument (SSJ-2) Kit was used to measured HFABP at admission and baseline soluble ST2 concentrations with Quantikine Human ST2/IL-1 R4 Immunoassay ELISA method. There were 34 subject, women and men and mean age was 55 years old. The mean HFABP at admission was 35,203 ng/mL. The mean of baseline soluble ST2 at admission was 33.114 ng/mL. There was strong correlation between concentration of HFABP at admision and baseline soluble ST2 at admission. There was strong correlation between concentrations of serum HFABP and baseline soluble ST2. [ABSTRACT FROM AUTHOR]