Synthesis Leishmanicidal Activities of bis-Schiff Bases of Isatins.

Twenty seven (27) derivatives of bis-Schiff bases of isatins 1-27 were studied for their leishmanicidal potential. Out of twenty seven (27) analogs, five exhibited varying degree of leishmanicidal activity with IC50 values 44.86 ± 0.66, 65.27 ± 0.38, 76.58 ± 0.30, 46.51 ± 0.36, and 84.05 ± 0.23 μM, and rests of the compounds showed no leishmanicidal activity. [ABSTRACT FROM AUTHOR]