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The Drosophila histone demethylase dKDM5/LID regulates hematopoietic development.
- Source :
-
Developmental Biology . Sep2015, Vol. 405 Issue 2, p260-268. 9p. - Publication Year :
- 2015
-
Abstract
- dKDM5/LID regulates transcription of essential developmental genes and, thus, is required for different developmental processes. Here, we report the essential contribution of dKDM5/LID to hematopoiesis in Drosophila . Our results show that dKDM5/LID is abundant in hemocytes and that its depletion induces over-proliferation and differentiation defects of larval hemocytes and disrupts organization of the actin cytoskeleton. We also show that dKDM5/LID regulates expression of key factors of hematopoietic development. In particular, dKDM5/LID depletion up-regulates expression of several transcription factors involved in hemocytes proliferation and differentiation as well as of several small-GTPases that link signaling effectors to actin cytoskeleton formation and dynamics. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00121606
- Volume :
- 405
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Developmental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 108966187
- Full Text :
- https://doi.org/10.1016/j.ydbio.2015.07.011