Back to Search
Start Over
Silver-Catalyzed Cross-Coupling of Isocyanides and Active Methylene Compounds by a Radical Process.
- Source :
-
Angewandte Chemie International Edition . Sep2015, Vol. 54 Issue 36, p10618-10622. 5p. - Publication Year :
- 2015
-
Abstract
- Isocyanides are versatile building blocks, and have been extensively exploited in CH functionalization reactions. However, transition-metal-catalyzed direct CH functionalization reactions with isocyanides suffer from over-insertion of isocyanides. Reported herein is a radical coupling/isomerization strategy for the cross-coupling of isocyanides with active methylene compounds through silver-catalysis. The method solves the over-insertion issue and affords a variety of otherwise difficult to synthesize β-aminoenones and tricarbonylmethanes under base- and ligand-free conditions. This report presents a new fundamental CC bond-forming reaction of two basic chemicals. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 54
- Issue :
- 36
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 109079101
- Full Text :
- https://doi.org/10.1002/anie.201504254