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Copper Catalyzed Enantioselective Alkylation of Pyrrole with β,-Unsaturated a-Ketoesters: Application to One-Pot Construction of the Seven-Membered Ring by Merging a Gold Catalysis.
- Source :
-
Organic Letters . Aug2015, Vol. 17 Issue 16, p4018-4021. 4p. - Publication Year :
- 2015
-
Abstract
- A highly enantioselective Friedel-Crafts alkylation of pyrrole to β,-unsaturated a-ketoesters was developed by virtue of a chiral copper complex, affording the alkylated derivatives of pyrrole with good yields and excellent enantioselectivities. Moreover, merging copper catalysis with gold catalysis realized a one-pot construction of the seven-membered ring to give annulated pyrroles with moderate to good yields and high enantiomeric excesses. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 17
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 109118106
- Full Text :
- https://doi.org/10.1021/acs.orglett.5b01917