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Discovery of characteristic chemical markers for inspecting sulfur-fumigated Radix Angelicae Sinensis by ultra-high performance liquid chromatography–quadrupole/time-of-flight mass spectrometry based metabolomics and chemical profiling approach.
- Source :
-
Food Research International . Oct2015, Vol. 76 Issue Part 3, p387-394. 8p. - Publication Year :
- 2015
-
Abstract
- An UHPLC–QTOF-MS/MS based metabolomics and chemical profiling approach was developed to identify the characteristic chemical markers for inspecting sulfur-fumigated Radix Angelicae Sinensis (S-RAS). Two sulfur-containing compounds in S-RAS were discovered and deduced to be (3 Z )-6-sulfite-ligustilide and (3 E )-6-sulfite-ligustilide. Furthermore, utilizing extraction ion method with the typical ion ( m/z 271.06) of (3 Z )-6-sulfite-ligustilide/(3 E )-6-sulfite-ligustilide as the diagnostic ion, another six sulfur-containing components were determined in S-RAS, and identified as 6, 8-disulfite-ligustilide and 8-sulfite-ligustilide or their isomers. The generation mechanisms of these compounds were proposed as the addition reaction of sulfurous acid with ( Z )-ligustilide and/or ( E )-ligustilide, two major naturally occurring components in RAS, at the double bonds of C6 C7 and C3 C8 positions. Using (3 Z )-6-sulfite-ligustilide and (3 E )-6-sulfite-ligustilide as the chemical markers, fourteen of sixteen batches of commercial RAS samples were inspected to be S-RAS, suggesting that the newly generated sulfur-containing compounds could be used as characteristic chemical markers for inspecting S-RAS among commercial RAS samples. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOMARKERS
*FUMIGATION
*QUADRUPOLES
*MASS spectrometry
*METABOLOMICS
Subjects
Details
- Language :
- English
- ISSN :
- 09639969
- Volume :
- 76
- Issue :
- Part 3
- Database :
- Academic Search Index
- Journal :
- Food Research International
- Publication Type :
- Academic Journal
- Accession number :
- 109180547
- Full Text :
- https://doi.org/10.1016/j.foodres.2015.05.055