Application of Good's buffers to pH imaging using hyperpolarized 13C MRI.

Authors :: Flavell, Robert R.
von Morze, Cornelius
Blecha, Joseph E.
Korenchan, David E.
Van Criekinge, Mark
Sriram, Renuka
Gordon, Jeremy W.
Chen, Hsin-Yu
Subramaniam, Sukumar
Bok, Robert A.
Wang, Zhen J.
Vigneron, Daniel B.
Larson, Peder E.
Kurhanewicz, John
Wilson, David M.
Source :: Chemical Communications. 9/25/2015, Vol. 71 Issue 74, p14119-14122. 4p.
Publication Year :: 2015
Abstract: N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its 13C chemical shift within the physiologic range. [ABSTRACT FROM AUTHOR]