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The Diagnostic Value of 18 F-FDG PET/CT in Association with Serum Tumor Marker Assays in Breast Cancer Recurrence and Metastasis.
- Source :
-
BioMed Research International . 3/24/2015, Vol. 2015, p1-5. 5p. - Publication Year :
- 2015
-
Abstract
- Background. After initial treatment of breast cancer (BC), monitoring locoregional recurrence and distant metastases is a great clinical challenge. Objective. To evaluate the efficacy of PET/CT in association with serum tumor makers in BC follow-up. Methods. Twenty-six women with a history of modified radical mastectomy were evaluated by 18F-FDG PET/CT. The results of PET/CT were compared with those of conventional imaging techniques (CITs) (including mammography, chest radiography, CT, MRI, ultrasound, and bone scintigraphy). Serum tumor markers of CEA, CA 125, and CA 15-3 in the BC patients were also analyzed in association with the results of PET/CT. Results. Compared with CITs, PET/CT was more sensitive to detect the malignant foci and had better patient-based sensitivity and specificity. The mean CA 15-3 serum level was significantly higher in the confirmed positive patients of PET/CT results than in the confirmed negative ones, while there were no significant differences in the serum levels of CEA and CA 125 of both groups. Conclusion. PET/CT is a highly efficient tool for BC follow-up compared with CITs. The high serum levels of CA 15-3 in confirmed positive PET/CT patients indicated the clinical value of CA 15-3 in BC follow-up. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACADEMIC medical centers
*MAMMOGRAMS
*BREAST tumors
*CANCER relapse
*CHEST X rays
*COMPUTED tomography
*METASTASIS
*RADIONUCLIDE imaging
*RESEARCH funding
*POSITRON emission tomography
*TUMOR markers
*ULTRASONIC imaging
*DATA analysis
*RETROSPECTIVE studies
*DATA analysis software
*DESCRIPTIVE statistics
*MANN Whitney U Test
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2015
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 109273766
- Full Text :
- https://doi.org/10.1155/2015/489021