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Predictive Value of Interim PET/CT in DLBCL Treated with R-CHOP: Meta-Analysis.
- Source :
-
BioMed Research International . 2/1/2015, Vol. 2015, p1-8. 8p. - Publication Year :
- 2015
-
Abstract
- Objective. We conducted a meta-analysis to evaluate the predictive value of interim 18F-FDG PET/CT in patients with DLBCL treated with R-CHOP chemotherapy. Methods. We searched for articles published in PubMed, ScienceDirect, Wiley, Scopus, and Ovid database from inception to March 2014. Articles related to interim PET/CT in patients with DLBCL treated with R-CHOP chemotherapy were selected. PFS with or without OS was chosen as the endpoint to evaluate the prognostic significance of interim PET/CT. Results. Six studies with a total of 605 cases were included. The sensitivity of interim PET/CT ranged from 21.2% to 89.7%, and the pooled sensitivity was 52.4%. The specificity of interim PET/CT ranged from 37.4% to 90.7%, and the pooled specificity was 67.8%. The pooled positive likelihood ratio and negative likelihood ratio were 1.780 and 0.706, respectively. The explained AUC was 0.6978 and the Q* was 0.6519. Conclusions. The sensitivity and specificity of interim PET/CT in predicting the outcome of DLBCL patients treated with R-CHOP chemotherapy were not satisfactory (52.4% and 67.8%, resp.). To improve this, some more work should be done to unify the response criteria and some more research to assess the prognostic value of interim PET/CT with semiquantitative analysis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *B cell lymphoma
*CANCER chemotherapy
*CHI-squared test
*COMPUTED tomography
*CONFIDENCE intervals
*DIAGNOSTIC errors
*MEDLINE
*META-analysis
*ONLINE information services
*STATISTICS
*POSITRON emission tomography
*SYSTEMATIC reviews
*DATA analysis
*RECEIVER operating characteristic curves
*ODDS ratio
*PROGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2015
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 109274834
- Full Text :
- https://doi.org/10.1155/2015/648572