The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.

Authors :: Khor, Bernard
Gagnon, John D.
Goel, Gautam
Roche, Marly I.
Conway, Kara L.
Tran, Khoa
Aldrich, Leslie N.
Sundberg, Thomas B.
Paterson, Alison M.
Mordecai, Scott
Dombkowski, David
Schirmer, Melanie
Tan, Pauline H.
Bhan, Atul K.
Roychoudhuri, Rahul
Restifo, Nicholas P.
O'Shea, John J.
Medoff, Benjamin D.
Shamji, Alykhan F.
Schreiber, Stuart L.
Source :: eLife. May2015, p1-27. 27p.
Publication Year :: 2015
Abstract: The article presents a study identifying a novel role for the dual specificity tyrosinephosphorylation-regulated kinase DYRK1A in regulating the balance with the use of an unbiased chemical biology approach.

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