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Pulmonary arterial hypertension in systemic lupus erythematosus may benefit by addition of immunosuppression to vasodilator therapy: an observational study.
- Source :
-
Rheumatology . Sep2015, Vol. 54 Issue 9, p1673-1679. 7p. 6 Charts. - Publication Year :
- 2015
-
Abstract
- Objective. To document changes in pulmonary arterial systolic pressure (PASP) in patients with SLE who have received CYC for any indication. Methods. Twenty-four patients with SLE pulmonary arterial hypertension (PAH) with a PASP of >30 mmHg by transthoracic echocardiography received i.v. CYC (n = 24) or steroids (n = 24) with or without vasodilators (n = 20). Baseline clinical characteristics and PASP were evaluated before and after therapy at 6 months. Responders were defined as those who had a decrease in PASP of >15mmHg from baseline along with improvement in their New York Heart Association functional class. Results. There were 11 responders (45.83%), with a decrease in mean PASP from 59.33 mmHg at baseline to 43.29 mmHg at the end of 6 months (P< 0.0001). The decrease in mean PASP from 39.75 mmHg at baseline to 34.4 mmHg at the end of 6 months was significant in four patients who received immunosuppression alone (P = 0.04). There was no difference in baseline PASP and disease activity between responders and non-responders. Two deaths were noted. Conclusion. Immunosuppression and vasodilators produced significant improvement in SLE PAH over 6 months. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14620324
- Volume :
- 54
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 109490832
- Full Text :
- https://doi.org/10.1093/rheumatology/kev097