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VisualCNA: a GUI for interactive constraint network analysis and protein engineering for improving thermostability.
- Source :
-
Bioinformatics . 7/15/2015, Vol. 31 Issue 14, p2394-2396. 3p. - Publication Year :
- 2015
-
Abstract
- Constraint network analysis (CNA) is a graph theory-based rigidity analysis approach for linking a biomolecule's structure, flexibility, (thermo)stability and function. Results from CNA are highly information-rich and require intuitive, synchronized and interactive visualization for a comprehensive analysis. We developed VisualCNA, an easy-to-use PyMOL plug-in that allows setup of CNA runs and analysis of CNA results linking plots with molecular graphics representations. From a practical viewpoint, the most striking feature of VisualCNA is that it facilitates interactive protein engineering aimed at improving thermostability. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MOLECULAR graphics
*DRUG design
*PROTEIN engineering
*COMPUTER software
Subjects
Details
- Language :
- English
- ISSN :
- 13674803
- Volume :
- 31
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Bioinformatics
- Publication Type :
- Academic Journal
- Accession number :
- 109560842
- Full Text :
- https://doi.org/10.1093/bioinformatics/btv139