Back to Search
Start Over
Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages
- Source :
-
International Immunopharmacology . Nov2003, Vol. 3 Issue 12, p1657. 9p. - Publication Year :
- 2003
-
Abstract
- In this study, we report evidences that Mycobacterium tuberculosis (MTB)-induced apoptosis in macrophages is reduced by a broad-spectrum hydroxamic acid-based matrix metalloproteinase (MMP) inhibitor, Batimastat (BB-94). In particular, we show that BB-94 administration to MTB-infected macrophages inhibits apoptosis and the downmodulation of membrane CD14 expression. Moreover, the addition of broad spectrum matrix metalloproteinase inhibitor to cell culture, during MTB infection, decreases the release of soluble TNF-α and leads to a simultaneous increase of membrane TNF-α. These results show that MTB-induced apoptosis in macrophages is reduced by a MMP inhibitor and most probably is related to TNF-α release. This identifies BB-94 as a simultaneous anti-apoptotic and anti-inflammatory molecule during MTB infection. [Copyright &y& Elsevier]
- Subjects :
- *MYCOBACTERIUM tuberculosis
*APOPTOSIS
*MACROPHAGES
*CELL death
*METALLOPROTEINASES
Subjects
Details
- Language :
- English
- ISSN :
- 15675769
- Volume :
- 3
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- International Immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 10984942
- Full Text :
- https://doi.org/10.1016/S1567-5769(03)00202-9