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Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans.
- Source :
-
Nature Cell Biology . Oct2015, Vol. 17 Issue 10, p1294-1303. 10p. 1 Diagram, 7 Charts, 8 Graphs. - Publication Year :
- 2015
-
Abstract
- Translation in eukaryotes is followed to detect toxins and virulence factors and coupled to the induction of defence pathways. Caenorhabditis elegans germline-specific mutations in translation components are detected by this system to induce detoxification and immune responses in distinct somatic cells. An RNA interference screen revealed gene inactivations that act at multiple steps in lipid biosynthetic and kinase pathways upstream of MAP kinase to mediate the systemic communication of translation defects to induce detoxification genes. Mammalian bile acids can rescue the defect in detoxification gene induction caused by C. elegans lipid biosynthetic gene inactivations. Extracts prepared from C. elegans with translation deficits but not from the wild type can also rescue detoxification gene induction in lipid-biosynthesis-defective strains. These eukaryotic antibacterial countermeasures are not ignored by bacteria: particular bacterial species suppress normal C. elegans detoxification responses to mutations in translation factors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14657392
- Volume :
- 17
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Nature Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 110030986
- Full Text :
- https://doi.org/10.1038/ncb3229