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Organocatalytic dynamic kinetic resolution of azlactones to construct chiral N-acyl amino acid oxime esters.
- Source :
-
Chemical Communications . 10/14/2015, Vol. 51 Issue 80, p14897-14900. 4p. - Publication Year :
- 2015
-
Abstract
- A direct strategy to obtain N-acyl amino acid oxime esters has been developed through the dynamic kinetic resolution of azlactones with oximes. In the presence of a chiral bisguanidinium salt catalyst, a variety of chiral N-acyl amino acid oxime esters were generated in excellent enantiomeric excesses (up to 97%) and high yields (up to 99%). The active oxime esters could be used in dipeptide synthesis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ORGANOCATALYSIS
*LACTONES
*CHIRALITY
*AMINO acids
*OXIMES
*ESTERS
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 51
- Issue :
- 80
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 110097420
- Full Text :
- https://doi.org/10.1039/c5cc05534b