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Anti-neuroinflammatory sesquiterpenes from Chinese eaglewood.
- Source :
-
Fitoterapia . Oct2015, Vol. 106, p115-121. 7p. - Publication Year :
- 2015
-
Abstract
- Nine new sesquiterpenes ( 1 – 9 ), together with seventeen known ones ( 10 – 26 ), were isolated from Chinese eaglewood. Their structures were established by extensive spectroscopic analysis, and the absolute configuration of 6 was determined by the modified Mosher's method. Compounds 7 , 10 , 14 , 15 , and 21 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC 50 values in the range 7.1–53.8 μM. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALTERNATIVE medicine
*ANIMAL experimentation
*ANTI-inflammatory agents
*BIOLOGICAL models
*PHYSICAL & theoretical chemistry
*DOSE-effect relationship in pharmacology
*MEDICINAL plants
*MICE
*NITRIC oxide
*SPECTRUM analysis
*PLANT extracts
*DESCRIPTIVE statistics
*IN vitro studies
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 106
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 110149347
- Full Text :
- https://doi.org/10.1016/j.fitote.2015.08.009