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Creatine kinase elevation caused by a combination of fluvastatin and telmisartan in a patient heterozygous for the CYP2C9*3 and ABCC2 -24C > T variants: a case report.
- Source :
-
BMC Research Notes . 2014, Vol. 7 Issue 1, p688-693. 6p. 1 Diagram, 2 Charts, 1 Graph. - Publication Year :
- 2014
-
Abstract
- Background: Genetic factors as predictor of the individual outcome of drug therapy is one aim of personalized medicine approaches. Case presentation: We report a drug metabolism based analysis of genetic polymorphisms in a Caucasian patient receiving fluvastatin and telmisartan experiencing myotoxicity (myalgia and moderate creatine kinase elevation). Conclusions: The obtained findings suggest that heterocygocity of cytochrome P450 CYP2C9*3 variant in combination with multidrug resistance-associated protein MRP2 -24C > T functions as risk factor predisposing to experience drug-drug interaction combing those drugs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17560500
- Volume :
- 7
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Research Notes
- Publication Type :
- Academic Journal
- Accession number :
- 110157512
- Full Text :
- https://doi.org/10.1186/1756-0500-7-688